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J Korean Med Sci. 2018 Jan 24;33(27):e75. doi: 10.3346/jkms.2018.33.e75. eCollection 2018 Jul 2.

Prevalence of BRAFV600E Mutation in Follicular Variant of Papillary Thyroid Carcinoma and Non-Invasive Follicular Tumor with Papillary-Like Nuclear Features (NIFTP) in a BRAFV600E Prevalent Area.

Author information

1
Hyereen Kim's Internal Medicine Clinic, Yangsan, Korea.
2
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
3
Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
4
Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea.
5
Department of Otolaryngology, Pusan National University School of Medicine, Busan, Korea.
6
Kim Yong Ki Internal Medicine Clinic, Busan, Korea.

Abstract

Background:

BRAFV600E mutation status and prevalence of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has not yet been reported in Korea. The aim of this study was to investigate the significance of the BRAFV600E mutation in the follicular variant of papillary thyroid carcinoma (FVPTC) and to determine the prevalence of NIFTP in BRAFV600E mutation-prevalent Korean patients.

Methods:

This study retrospectively analyzed 1,417 consecutive patients who underwent total thyroidectomy with routine prophylactic central lymph node dissection for papillary thyroid carcinoma (PTC). BRAFV600E mutation analysis was performed routinely using multiplex polymerase chain reaction by applying dual priming oligonucleotide. Clinicopathological characteristics and ultrasonographic findings were compared between BRAFV600E mutation-positive and -negative groups for FVPTC. Pathologists reviewed the pathology slides according to consensus diagnostic criteria for the encapsulated FVPTC and NIFTP.

Results:

The prevalence of the BRAFV600E mutation in all subtypes of PTC was 61.0% (861/1,411). FVPTC presented a BRAFV600E mutation rate of 27.3%. The FVPTC patients with BRAFV600E mutation were older than those with no BRAFV600E mutation (P = 0.021). The prevalence of NIFTP was 0.18% among all PTC patients (2/1,411) and the proportion of NIFTP among FVPTC was 9.1% (2/22).

Conclusion:

The BRAFV600E mutation is prevalent in Korean patients with FVPTC in a region with high frequency of the BRAFV600E mutation and very low prevalence of NIFTP compared with that reported in western studies.

KEYWORDS:

B-type Raf (BRAF); Follicular Variant; NIFTP; Papillary Carcinoma; Thyroid Carcinoma

PMID:
29962924
PMCID:
PMC6021356
DOI:
10.3346/jkms.2018.33.e75
[Indexed for MEDLINE]
Free PMC Article

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