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Trends Parasitol. 2018 Aug;34(8):664-682. doi: 10.1016/j.pt.2018.05.005. Epub 2018 Jun 27.

Strategies to Optimize the Efficacy of Anthelmintic Drugs in Ruminants.

Author information

1
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CICPBA, Facultad de Ciencias Veterinarias, Campus Universitario, (7000) Tandil, Argentina. Electronic address: clanusse@vet.unicen.edu.ar.
2
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CICPBA, Facultad de Ciencias Veterinarias, Campus Universitario, (7000) Tandil, Argentina.
3
Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, Brazil.

Abstract

Anthelmintic resistance in human and animal pathogenic helminths has been spreading in prevalence and severity. Multidrug resistance is a widespread problem in livestock animals. The use of available pharmacology-based information is critical to the design of successful future approaches for parasite control. Relevant scientific work supporting the main strategies to optimize anthelmintic therapy in ruminants under the current drug-resistance scenario is described here. We emphasize the need for further integrated pharmaco-parasitological knowledge to extend the lifespan of both traditional and novel anthelmintic compounds, and to progress in the identification of complementary/alternative measures of parasite control in livestock animals.

KEYWORDS:

anthelmintic pharmacotherapy; bioactive phytochemicals; drug combinations; drug resistance; pharmacokinetic-based improvement on anthelmintic activity; ruminants

PMID:
29960843
DOI:
10.1016/j.pt.2018.05.005
[Indexed for MEDLINE]

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