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Environ Int. 2018 Oct;119:186-192. doi: 10.1016/j.envint.2018.06.027. Epub 2018 Jun 27.

Fine particulate matter constituents and stress hormones in the hypothalamus-pituitary-adrenal axis.

Author information

1
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China.
2
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Meteorology and Health, Shanghai 200030, China.
3
Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA.
4
Shanghai Key Laboratory of Meteorology and Health, Shanghai 200030, China.
5
Department of Neonates, Children's Hospital, Fudan University, Shanghai 201102, China.
6
Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.
7
Shanghai Environmental Monitoring Center, Shanghai 200235, China.
8
Shanghai Environmental Monitoring Center, Shanghai 200235, China. Electronic address: qingyanf@semc.gov.cn.
9
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China; Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Parenthood Research, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China. Electronic address: kanh@fudan.edu.cn.

Abstract

Fine particulate matter (PM2.5) has recently been associated with the activation of the hypothalamus-pituitary-adrenal (HPA) axis, increasing cardiometabolic risks. However, it is unknown which constituents of PM2.5 were mainly responsible for these associations. In a longitudinal panel study with 4 repeated measurements among 43 college students in Shanghai, China, we measured serum levels of corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and cortisol, as indicators of HPA axis activation. Then, we evaluated the associations of 22 constituents of PM2.5 with these stress hormones using linear mixed-effect models. During the study period, the average daily concentration of PM2.5 was 41.1 μg/m3. We found that short-term exposure to PM2.5 was associated with elevated levels of the 3 stress hormones. We observed that water-soluble inorganic ions, especially nitrate (NO3-) and ammonium, had stronger influences on 3 hormones. Six metallic elements, including Zn, Mn, Cu, Fe, Br, and Cr, had positive but generally instable associations with 3 hormones. The effects of organic carbon and elemental carbon on hormones were generally weak. When correcting for multiple comparisons using false discovery rate, NO3- was still significantly associated with CRH, but other important associations turned to be insignificant. An interquartile range increase in NO3- on the previous day were associated with 12.13% increase (95% confidence interval: 4.45%, 20.37%) in CRH. Our findings suggested that water-soluble inorganic constituents of PM2.5 (especially, NO3-) might have stronger influences on the activation of HPA axis than carbonaceous and elemental components.

KEYWORDS:

Chemical constituents; Fine particulate matter; Hypothalamus–pituitary–adrenal axis; Panel study; Stress hormones

PMID:
29960262
DOI:
10.1016/j.envint.2018.06.027
[Indexed for MEDLINE]

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