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Nat Commun. 2018 Jun 29;9(1):2549. doi: 10.1038/s41467-018-04997-w.

2D transition metal dichalcogenides with glucan multivalency for antibody-free pathogen recognition.

Author information

1
Department of Chemical Engineering, Hanyang University, Ansan, 426-791, Republic of Korea.
2
Department of Chemical and Molecular Engineering, Hanyang University, Ansan, 426-791, Republic of Korea.
3
Department of Chemical and Molecular Engineering, Hanyang University, Ansan, 426-791, Republic of Korea. sulee@hanyang.ac.kr.
4
Department of Chemical Engineering, Hanyang University, Ansan, 426-791, Republic of Korea. kjh75@hanyang.ac.kr.

Abstract

The ability to control the dimensions and properties of nanomaterials is fundamental to the creation of new functions and improvement of their performances in the applications of interest. Herein, we report a strategy based on glucan multivalent interactions for the simultaneous exfoliation and functionalization of two-dimensional transition metal dichalcogenides (TMDs) in an aqueous solution. The multivalent hydrogen bonding of dextran with bulk TMDs (WS2, WSe2, and MoSe2) in liquid exfoliation effectively produces TMD monolayers with binding multivalency for pathogenic bacteria. Density functional theory simulation reveals that the multivalent hydrogen bonding between dextran and TMD monolayers is very strong and thermodynamically favored (ΔEb = -0.52 eV). The resulting dextran/TMD hybrids (dex-TMDs) exhibit a stronger affinity (Kd = 11 nM) to Escherichia coli O157:H7 (E. coli) than E. coli-specific antibodies and aptamers. The dex-TMDs can effectively detect a single copy of E. coli based on their Raman signal.

PMID:
29959329
PMCID:
PMC6026184
DOI:
10.1038/s41467-018-04997-w
[Indexed for MEDLINE]
Free PMC Article

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