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Nature. 1985 Sep 19-25;317(6034):230-4.

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.


A 'rescuable' plasmid containing globin gene sequences allowing recombination with homologous chromosomal sequences has enabled us to produce, score and clone mammalian cells with the plasmid integrated into the human beta-globin locus. The planned modification was achieved in about one per thousand transformed cells whether or not the target gene was expressed.

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