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Biomed Pharmacother. 2018 Oct;106:163-174. doi: 10.1016/j.biopha.2018.06.109. Epub 2018 Jun 27.

Endometriosis: Perspective, lights, and shadows of etiology.

Author information

1
Department of Medical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran.
2
Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran.
3
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz Iran.
5
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz Iran; Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Yousefime@tbzmed.ac.ir.

Abstract

Endometriosis refers to the growth of ectopic endometrial tissue outside the uterine cavity. About 10-15% of female in reproductive age suffer from endometriosis. Several etiologies - such as oxidative stress, inflammatory factors and cytokines, genetic etiology, and hormone role - have been reported for endometriosis. Indeed, oxidative stress leads to abnormalities by the production of ROS and RNS. The mechanism of endometriosis genesis is a complicated process that concerns the alterations in cellular immunity. Also, endometriosis is a hormonal response that illustrates stimulation in steroid hormone production. Genetic polymolymorphisms and epigenetic factors are also important in endometriosis initiation and progression. This review paper presents the role of oxidative stress, reactive oxygen species (ROS), and antioxidants and inflammatory, genetic, and epigenetic factors involved in the initiation and progression of the endometriosis.

KEYWORDS:

Endometriosis; Hormone and genetic; Inflammatory chemokine; Oxidative stress

PMID:
29958140
DOI:
10.1016/j.biopha.2018.06.109
[Indexed for MEDLINE]

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