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Respir Med. 2018 Jul;140:32-38. doi: 10.1016/j.rmed.2018.05.011. Epub 2018 May 14.

Association between serum 25-hydroxyvitamin D levels and pulmonary function, among Korean adults, during 2010-2014, by sex, age, and body mass index.

Author information

1
Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea; Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
2
Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea; Institute of Health Service Research, Yonsei University, Seoul, Republic of Korea.
3
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
4
Institute of Health Service Research, Yonsei University, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
5
Institute of Health Service Research, Yonsei University, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: JANGSI@yuhs.ac.

Abstract

BACKGROUND:

This study examined the association between serum 25-hydroxyvitamin D (25(OH)D) and pulmonary function, among Korean adults, from 2010 to 2014.

METHODS:

The data were obtained from the fifth Korea National Health and Nutrition Examination Survey (KNHANES 5), and the first and second year (2013-2014) of KNHANES 6. The study population comprised 14,378 individuals. The variable of interest was serum 25(OH)D, and the dependent variable, pulmonary function.

RESULTS:

All people with vitamin D levels below 30 ng/ml had lower lung functions, which was significant in lower forced expiratory volume in the first second (FEV1) (serum 25(OH)D < 10 ng/ml, 20 to <30 ng/ml: P = .001, 10 to <20 ng/ml: P = 0) and forced vital capacity (FVC) (serum 25(OH)D level <10 ng/ml: P = .01, 10 to < 20 ng/ml: P = .001, 20 to <30 ng/ml: P = .008). The lower the serum 25(OH)D, the lower the levels of FEV1 in men and this was significant. (serum 25(OH)D < 10 ng/ml: P = .007, 10 to <20 ng/ml: P = .002, 20 to <30 ng/ml: P = .007). The values of FEV1 and FVC were lower in people aged 50-69 years when vitamin D was lower than 30 ng/ml which were all significant. Among participants with BMI values < 23 kg/m2, lower vitamin D levels were significantly associated with lower pulmonary function.

CONCLUSIONS:

We found a significant association between serum 25(OH)D and pulmonary function, and this was related to sex, age and body mass index.

KEYWORDS:

Epidemiology; Pulmonary function; Serum 25-hydroxyvitamin D

PMID:
29957277
DOI:
10.1016/j.rmed.2018.05.011
[Indexed for MEDLINE]

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