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Methods Mol Biol. 2018;1799:353-358. doi: 10.1007/978-1-4939-7896-0_25.

The Use of Biodegradable Nanoparticles for Tolerogenic Therapy of Allergic Inflammation.

Author information

1
Department of Microbiology-Immunology and Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
2
Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
3
Department of Microbiology-Immunology and Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. s-d-miller@northwestern.edu.

Abstract

Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.

KEYWORDS:

Allergy; Immunotherapy; Nanoparticles; Th2; Tolerance

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