Format

Send to

Choose Destination
Alzheimers Dement (N Y). 2018 May 22;4:224-233. doi: 10.1016/j.trci.2018.03.010. eCollection 2018.

Neural correlates of episodic memory in the Memento cohort.

Author information

1
Institut de la mémoire et de la maladie d'Alzheimer, Département de neurologie, Hôpital de la Pitié Salpêtrière, Paris, France.
2
Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, and Inserm, U 1127, and CNRS UMR 7225, and ICM, Paris, France.
3
Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France.
4
CHU de Bordeaux, Pole Santé Publique, Bordeaux, France.
5
CATI Multicenter Neuroimaging platform, http://cati-neuroimaging.com, Gif sur Yvette, France.
6
Neurospin, DRF, CEA, Paris Saclay University, Gif sur Yvette, France.
7
Institut de psychologie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
8
Inserm UMR 894, Centre de psychiatrie et neurosciences, Laboratoire mémoire et cognition, Paris, France.
9
Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
10
Département de Médecine Nucléaire, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
11
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
12
Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
13
Univ Lille, Inserm 1171, CHU, Centre Mémoire (CMRR) Distalz, Lille, France.
14
CHU de Bordeaux, CMRR, Pôle Neurosciences, Bordeaux, France.
15
Centre Mémoire (CMRR), Hôpital Universitaire de Strasbourg, Département de Gériatrie, Hôpital de Jour Gériatrique, Strasbourg, France.
16
Department of Neurology and Memory Research and Resources Center, Gui de Chauliac University Hospital, Montpellier, France.
17
CHRU de Montpellier, Université de Montpellier, Institute of Regenerative Medicine and Bio-therapy (IRMB), INSERM U1183, CCBHM, Laboratoire de Biochimie Protéomique Clinique, Montpellier, France.
18
Université Aix-Marseille, INSERM, Institut des Neurosciences des Systèmes (INS) UMR 1106, Marseille, France.
19
APHM, Hôpitaux de la Timone, Service de Neurologie et de Neuropsychologie, Marseille, France.
20
Clinical and Research Memory Center of Lyon, Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France.
21
Centre Mémoire (CMRR) Paris Nord Ile de France, Groupe Hospitalier Lariboisiere FW Saint-Louis, APHP, Université Paris Diderot, Paris, France.
22
Service de Gériatrie, Université Paris Descartes, Hôpital Broca, Paris, France.
23
Département de Neurologie, Hôpital universitaire et faculté of Médecine, Dijon, France.
24
Centre Mémoire de Ressources et de Recherche, CHU de Nice, EA COBTeK, Université Côte d'Azur, Nice, France.

Abstract

Introduction:

The free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.

Methods:

We investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose-positron emission tomography evaluations.

Results:

Encoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions.

Discussion:

The neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.

KEYWORDS:

Alzheimer's disease; Fluorodeoxyglucose-PET; MRI; Memory; Multicenter cohort

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center