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Haematologica. 2018 Nov;103(11):1881-1888. doi: 10.3324/haematol.2018.192526. Epub 2018 Jun 28.

Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study.

Author information

1
Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
2
Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Spain.
3
Epidemiology Unit and Girona Cancer Registry, Catalan Institute of Oncology, Girona, Spain.
4
Cancer Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
5
Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain.
6
Unit of Molecular Epidemiology and Genetic in Infections and Cancer (UNIC-Molecular), Cancer Epidemiology Research Programme (IDIBELL), Catalan Institute of Oncology, L' Hospitalet De Llobregat, Spain.
7
Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain.
8
ISGlobal, Barcelona, Spain.
9
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
10
Unit of Information and Interventions in Infections and Cancer (UNIC-I&I), Cancer Epidemiology Research Programme, (IDIBELL), Catalan Institute of Oncology, L' Hospitalet De Llobregat, Spain.
11
Hematology, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
12
Hematology Laboratory, Department of Pathology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
13
Hospital Clinic de Barcelona, University of Barcelona, CIBERONC, Barcelona Spain.
14
University of Cantabria - Marqués de Valdecilla Research Institute (IDIVAL), Santander, Spain.
15
University Institute of Oncology (IUOPA), University of Oviedo, Spain.
16
Department of Preventive Medicine and Public Health, University of Granada, Spain.
17
Instituto de Investigación Biosanitaria de Granada, Hospitales Universitarios de Granada, Spain.
18
Hematology Department, Hospital del Mar, Barcelona, Spain.
19
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
20
Epidemiology Section, Public Health Division, Department of Health of Madrid, Spain.
21
PATH, Reproductive Health, Seattle, WA, USA.
22
Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Madrid, Spain dcasabonne@iconcologia.net.

Abstract

Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.

PMID:
29954942
PMCID:
PMC6278961
DOI:
10.3324/haematol.2018.192526
[Indexed for MEDLINE]
Free PMC Article

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