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Cytokine. 2018 Jun 25. pii: S1043-4666(18)30116-9. doi: 10.1016/j.cyto.2018.03.030. [Epub ahead of print]

IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies.

Author information

1
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
2
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, United States.
3
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: tsunga@upmc.edu.

Abstract

Acute inflammation following sterile injury is both inevitable and necessary to restore homeostasis and promote tissue repair. However, when excessive, inflammation can jeopardize the viability of organs and cause detrimental systemic effects. Identifying key-regulators of the immune cascade induced by surgery is vital to attenuating excessive inflammation and its subsequent effects. In this review, we describe the emerging role of IL-17A as a key-regulator in acute inflammation. The role of IL-17A in chronic disease states, such as rheumatoid arthritis, psoriasis and cancer has been well documented, but its significance in acute inflammation following surgery, sepsis, or traumatic injury has not been well studied. We aim to highlight the role of IL-17A in acute inflammation caused by trauma, liver ischemia, and organ transplantation, as well as in post-operative surgical infections. Further investigation of the roles of this cytokine in acute inflammation may stimulate novel therapies or diagnostic modalities.

KEYWORDS:

Acute inflammation; Computational modeling; IL-17A

PMID:
29954675
DOI:
10.1016/j.cyto.2018.03.030

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