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Ital J Pediatr. 2018 Jun 28;44(1):74. doi: 10.1186/s13052-018-0517-6.

Common symptoms for a rare disease in a girl with sarcoidosis: a case report.

Author information

1
University of Florence, piazza di San Marco, 4, 50121, Florence, Italy.
2
University of Trieste, via dell'Istria, 65/1, 34100, Trieste, Italy. giovanna.ferrara@gmail.com.
3
Anatomic Pathology Unit, Meyer Children's University Hospital, viale Pieraccini, 24, 50139, Florence, Italy.
4
Anna Meyer Children's University Hospital, viale Pieraccini, 24, 50139, Florence, Italy.

Abstract

BACKGROUND:

Sarcoidosis in pediatric age is uncommon and challenging diagnosis, because manifestations can be significantly variable and non-specific since it is a multisystem disease, and virtually any organ system may be involved.

CASE PRESENTATION:

In this report, we describe the case of a 12-year-old girl presenting with fatigue and weight loss, with a painless hepato-splenomegaly without additional clinical signs on physical examination. In our patient, once we had ruled out infections, malignancies and granulomatous diseases of childhood, we made diagnosis of sarcoidosis, finding suggestive histological features in two different tissues (liver and lymph nodes) with lung involvement.

CONCLUSIONS:

Our case points out that pediatricians should consider sarcoidosis in the differential diagnosis in case of systemic symptoms, even in absence of other specific clinical clues, because they represent the most common clinical manifestations on presentation in children, in order to refer promptly the young patient to specialist evaluation.

KEYWORDS:

Asthenia; Hepato-splenomegaly; Lymphadenopathy; Mycophenolate mofetil; Paediatric sarcoidosis

PMID:
29954416
PMCID:
PMC6025712
DOI:
10.1186/s13052-018-0517-6
[Indexed for MEDLINE]
Free PMC Article

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