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Free Radic Biol Med. 2018 Sep;125:44-52. doi: 10.1016/j.freeradbiomed.2018.06.011. Epub 2018 Jun 25.

How the phagocyte NADPH oxidase regulates innate immunity.

Author information

1
Department of Medicine, University of Cambridge School of Clinical Medicine, Box 157 Cambridge Biomedical Campus, Cambridge CB2 0QQ, United Kingdom. Electronic address: tdct2@cam.ac.uk.

Abstract

The phagocyte NADPH oxidase is a multi subunit protein complex that generates reactive oxygen species at cell membranes and within phagosomes. It is essential for host defence as evidenced by the severe immunodeficiency syndrome caused by a loss of one of the subunits. This is known as chronic granulomatous disease (CGD). However, the phagocyte NADPH oxidase also has a key role to play in regulating immunity and it is notable that chronic granulomatous disease is also characterised by autoimmune and autoinflammatory manifestations. This is because reactive oxygen species play a role in regulating signalling through their ability to post-translationally modify amino acid residues such as cysteine and methionine. In this review, I will outline the major aspects of innate immunity that are regulated by the phagocyte NADPH oxidase, including control of transcription, autophagy, the inflammasome and type 1 interferon signalling.

KEYWORDS:

Autophagy; Chronic granulomatous disease; Inflammasome; Reactive oxygen species; Type 1 interferon

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