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PLoS One. 2018 Jun 28;13(6):e0199679. doi: 10.1371/journal.pone.0199679. eCollection 2018.

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

Author information

1
Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
2
Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
3
Departamento de Bioquímica, UAM, Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC-UAM, IdiPAZ, Madrid, Spain.
4
Centro de Investigación Biomédica en Red, CIBERONC, Madrid, Spain.
5
Section of Clinical and Molecular Dermatology, Department of Dermatology, Venereology and Allergology and European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
6
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, United Kingdom.
7
Department of Physics, King's College London, Strand, London, United Kingdom.

Abstract

Lysyl oxidase-like 2 (LOXL2) is a copper-dependent monoamine oxidase that contributes to the remodelling of the extracellular matrix (ECM) by cross linkage of collagen and elastin fibres and has emerged as a potential therapeutic target in cancer and fibrosis. In the skin, LOXL2 is essential for epidermal cell polarity and differentiation. However, its role in the dermis has not been evaluated. We found that Loxl2 is dispensable for mouse dermal development, maturation and homeostasis, yet affects dermal stiffness. Neither loss of Loxl2 nor increased Loxl2 expression affected dermal architecture following treatment with the phorbol ester TPA. Furthermore, Loxl2 expression did not alter the stroma of DMBA-TPA-induced tumours. We conclude that, although Loxl2 is expressed in both dermis and epidermis, its function appears largely confined to the epidermis.

PMID:
29953488
PMCID:
PMC6023175
DOI:
10.1371/journal.pone.0199679
[Indexed for MEDLINE]
Free PMC Article

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