Format

Send to

Choose Destination
Sleep Breath. 2019 Mar;23(1):227-233. doi: 10.1007/s11325-018-1688-5. Epub 2018 Jun 27.

Metoprolol has a similar therapeutic effect as amlodipine on BP lowering in hypertensive patients with obstructive sleep apnea.

Author information

1
Cardiovascular Department, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
2
Cardiovascular Department, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China. ly99ly@vip.163.com.
3
Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, People's Republic of China. ly99ly@vip.163.com.

Abstract

PURPOSE:

β-Blocker use has been controversial for a long time in the management of hypertensive patients with obstructive sleep apnea (OSA). The aim of present study was to compare the effects of metoprolol on BP lowering with amlodipine in hypertensive OSA patients.

METHODS:

Hypertensive subjects with OSA were randomly assigned to metoprolol and amlodipine groups, receiving 12 weeks of oral either metoprolol (47.5 mg once daily) or amlodipine (5 mg once daily) treatment. At baseline and after the 12-week treatment period, 24-h ambulatory blood pressure monitoring was performed in both groups.

RESULTS:

Both of metoprolol and amlodipine treatments significantly lowered 24-h blood pressure (BP) (from 143/88 to 132.3/81.6 mmHg; from 141.3/84.5 to 133.7/80.8 mmHg), daytime BP (from 146/90.2 to 136.4/84.6 mmHg; from 145.1/87.6 to 138.2/84.1 mmHg), and nighttime BP (from 139.1/83.9 to 125.7/76.2 mmHg; from 134.5/78.5 to 125.8/74.1 mmHg) (all P < 0.05). But there were no significant differences between the groups in BP variability (P > 0.05). Besides, metoprolol significantly reduced daytime heart rate (HR) (P < 0.05), while 24-h and nighttime HR values had no remarkable changes compared with baseline (P > 0.05).

CONCLUSIONS:

Metoprolol had similar therapeutic effects on BP lowering as amlodipine and could not decrease HR during the nighttime in hypertensive patients with OSA.

KEYWORDS:

Blood pressure; Calcium channel blockers; Hypertension; Obstructive sleep apnea; β1-Blockers

PMID:
29951886
DOI:
10.1007/s11325-018-1688-5

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center