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Adv Exp Med Biol. 2018;1076:257-276. doi: 10.1007/978-981-13-0529-0_14.

Metabolomics: State-of-the-Art Technologies and Applications on Drosophila melanogaster.

Author information

1
Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan.
2
Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Aachen, Germany.
3
Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan. fukusaki@bio.eng.osaka-u.ac.jp.

Abstract

Metabolomics is one of the latest "omics" technology concerned with the high-throughput identification and quantification of metabolites, the final products of cellular processes. The revealed data provide an instantaneous snapshot of an organism's metabolic pathways, which can be used to explain its phenotype or physiology. On the other hand, Drosophila has shown its power in studying metabolism and related diseases. At this stage, we have the state-of-the-art knowledge in place: a potential candidate to study cellular metabolism (Drosophila melanogaster) and a powerful methodology for metabolic network decipherer (metabolomics). Yet missing is advanced metabolomics technologies like isotope-assisted metabolomics optimized for Drosophila. In this chapter, we will discuss on the current status and future perspectives in technologies and applications of Drosophila metabolomics.

KEYWORDS:

Drosophila; Metabolism; Metabolomics; State of the art

PMID:
29951824
DOI:
10.1007/978-981-13-0529-0_14
[Indexed for MEDLINE]

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