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Front Immunol. 2018 Jun 5;9:1283. doi: 10.3389/fimmu.2018.01283. eCollection 2018.

The Role of Mitophagy in Innate Immunity.

Author information

1
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece.
2
Department of Biology, University of Crete, Heraklion, Greece.
3
Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece.

Abstract

Mitochondria are cellular organelles essential for multiple biological processes, including energy production, metabolites biosynthesis, cell death, and immunological responses among others. Recent advances in the field of immunology research reveal the pivotal role of energy metabolism in innate immune cells fate and function. Therefore, the maintenance of mitochondrial network integrity and activity is a prerequisite for immune system homeostasis. Mitochondrial selective autophagy, known as mitophagy, surveils mitochondrial population eliminating superfluous and/or impaired organelles and mediating cellular survival and viability in response to injury/trauma and infection. Defective removal of damaged mitochondria leads to hyperactivation of inflammatory signaling pathways and subsequently to chronic systemic inflammation and development of inflammatory diseases. Here, we review the molecular mechanisms of mitophagy and highlight its critical role in the innate immune system homeostasis.

KEYWORDS:

autophagy; energy homeostasis; immunity; inflammation; macrophages; metabolism; mitochondria; mitophagy

PMID:
29951054
PMCID:
PMC6008576
DOI:
10.3389/fimmu.2018.01283
[Indexed for MEDLINE]
Free PMC Article

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