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Nat Rev Cardiol. 2018 Oct;15(10):631-647. doi: 10.1038/s41569-018-0046-4.

The epicardium as a hub for heart regeneration.

Cao J1,2,3, Poss KD4,5.

Author information

1
Department of Cell Biology, Duke University Medical Center, Durham, NC, USA. jic4001@med.cornell.edu.
2
Regeneration Next, Duke University, Durham, NC, USA. jic4001@med.cornell.edu.
3
Cardiovascular Research Institute, Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA. jic4001@med.cornell.edu.
4
Department of Cell Biology, Duke University Medical Center, Durham, NC, USA. kenneth.poss@duke.edu.
5
Regeneration Next, Duke University, Durham, NC, USA. kenneth.poss@duke.edu.

Abstract

After decades of directed research, no effective regenerative therapy is currently available to repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops the heart in all vertebrates, has emerged as a new player in cardiac repair and regeneration. The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium also participates in fibrotic responses in mammalian hearts. This structure serves as a source of crucial cells, such as vascular smooth muscle cells, pericytes, and fibroblasts, during heart development and repair. The epicardium also secretes factors that are essential for proliferation and survival of cardiomyocytes. In this Review, we describe recent advances in our understanding of the biology of the epicardium and the effect of these findings on the candidacy of this structure as a therapeutic target for heart repair and regeneration.

PMID:
29950578
PMCID:
PMC6143401
[Available on 2019-10-01]
DOI:
10.1038/s41569-018-0046-4

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