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AJR Am J Roentgenol. 2018 Aug;211(2):246-259. doi: 10.2214/AJR.18.19822. Epub 2018 Jun 27.

PET/CT of Dementia.

Author information

1
1 Department of Medicine, McMaster University, 1200 Main St W, Rm 1P11, Hamilton, ON L8N 3Z5. Canada.
2
2 Department of Radiology, McMaster University, Hamilton, ON, Canada.
3
3 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
4
4 Departments of Medical Imaging, Medicine, and Biomedical Engineering, University of Arizona, Tucson, AZ.
5
5 Department of Medical Imaging, University of Toronto and the University Health Network, Toronto Western Hospital, Toronto, ON, Canada.
6
6 Douglas Research Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
7
7 Department of Medicine, Neurology Division, Toronto Western Hospital, University of Health Network; Krembil Research Institute, University of Health Network; and Research Imaging Centre, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.
8
8 Department of Radiology, UT Southwestern Medical Center, Dallas, TX.
9
9 Department of Medicine, Neurology Division, University of Toronto, and the Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, Canada.

Abstract

OBJECTIVE:

In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field.

CONCLUSION:

Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.

KEYWORDS:

PET/CT; amyloid; dementia; imaging; tau

PMID:
29949415
DOI:
10.2214/AJR.18.19822

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