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Obes Surg. 2018 Oct;28(10):2998-3006. doi: 10.1007/s11695-018-3316-7.

A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Acetaminophen on Hospital Length of Stay in Obese Individuals Undergoing Sleeve Gastrectomy.

Author information

1
Department of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, Room A-1050, New York, NY, 10065, USA.
2
Department of Surgery, Weill Cornell Medical College, New York, NY, USA.
3
Department of Healthcare Policy and Research (Division of Biostatistics and Epidemiology), Weill Cornell Medical College, New York, NY, USA.
4
Department of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, Room A-1050, New York, NY, 10065, USA. pag2014@med.cornell.edu.
5
Department of Medicine, Weill Cornell Medical College, New York, NY, USA. pag2014@med.cornell.edu.

Abstract

BACKGROUND:

Retrospective studies indicate that acetaminophen iv administration reduces hospital length of stay (LoS) and opiate consumption in patients undergoing bariatric surgery.

OBJECTIVE:

This study sought to determine whether using acetaminophen iv in morbidly obese subjects undergoing sleeve gastrectomy decreased LoS and total hospital charges as compared to patients receiving saline placebo.

SETTING:

Single-center university hospital METHODS: Using a randomized, double-blind, placebo-controlled design, subjects were assigned to receive either acetaminophen iv (group A) or saline placebo iv (group P). Data were collected between Jan 1 and Dec 31, 2016. Group A received acetaminophen every 6 h for a total of four doses. The first dose was administered following the induction of general anesthesia; group P received saline iv on the same schedule. Anesthetic management and prophylactic antiemetic regimen were standardized in all subjects. Postoperative pain management consisted of hydromorphone via patient-controlled infusion pump. Primary outcomes include hospital LoS and associated hospital costs. Secondary outcomes include patient satisfaction and postoperative nausea and pain scores.

RESULTS:

Subject demographics (n = 127) and intraoperative management were similar in the two groups. Across all subjects, median hospital LoS in group A (n = 63) was 1.87 vs. 1.97 days in group P (n = 64) (p = 0.03, Wilcoxon rank-sum test). Postoperatively, daily quality-of-recovery (QoR-15) scores, narcotic consumption, and the use of rescue antiemetics were not significantly different between groups. Median hospital costs were as follows: group A, $12,885 vs. group P, $12,977 (n = 64).

CONCLUSIONS:

Acetaminophen iv may reduce hospital LoS in subjects undergoing sleeve gastrectomy.

KEYWORDS:

Acetaminophen; Double blind; Obesity; Placebo; Prospective; RCT; Randomized controlled trial; Surgery

PMID:
29948869
DOI:
10.1007/s11695-018-3316-7

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