Format

Send to

Choose Destination
J Bone Miner Metab. 2019 Mar;37(2):368-375. doi: 10.1007/s00774-018-0934-z. Epub 2018 Jun 14.

Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people.

Author information

1
Department of Physical Therapy, Faculty of Medical Technology, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, Niigata, 950-3198, Japan. m-sakuma@nuhw.ac.jp.
2
Department of Orthopedic Surgery, Niigata University Medical and Dental Hospital, Niigata, Japan. m-sakuma@nuhw.ac.jp.
3
Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
4
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
5
Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
6
Center for Inter-Organ Communication Research, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
7
Department of Molecular Neuroscience, Resource Branch for Brain Disease Research, Brain Research Institute, Niigata University, Niigata, Japan.
8
Sado General Hospital, Sado, Japan.
9
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Abstract

It has been reported that many elderly people have low serum levels of 25-hydroxyvitamin D [25(OH)D] and that serum 25(OH)D levels may have a relationship with cognitive function. The aim of this study was to examine the relationship between serum 25(OH)D levels and cognitive function in a Japanese population. This cross-sectional study was performed as a part of the Project in Sado for Total Health (PROST). The PROST study evaluated cognitive state and serum vitamin D level from June 2011 to November 2013 for 740 patients (431 men and 309 women). The Mini-Mental State Examination-Japanese version (MMSE-J) and serum 25(OH)D level measurements were used as assessment tools. Cognitive impairment was defined using MMSE-J ≤ 23 as a cutoff. Multiple logistic regression analyses were performed to calculate the odds ratios (ORs) for low MMSE-J scores. The average subject age was 68.1 years, the average MMSE- J score was 25.9, and the average 25(OH)D level was 24.6 ng/mL. Significant ORs for cognitive impairment were observed for both high age and low serum 25(OH)D. The adjusted OR for the lowest versus highest serum 25(OH)D quartiles was 2.70 (95% confidence interval 1.38-5.28, P = 0.0110). Low serum 25(OH)D levels were independently associated with a higher prevalence of cognitive impairment.

KEYWORDS:

25-Hydroxyvitamin D; Cognitive impairment; Cross-sectional study; Mini-Mental State Examination-Japanese Version (MMSE-J)

PMID:
29948345
DOI:
10.1007/s00774-018-0934-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center