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J Clin Endocrinol Metab. 2018 Sep 1;103(9):3260-3266. doi: 10.1210/jc.2018-00187.

No Correlation of Pancreatic Fat and β-Cell Function in Young Women With and Without a History of Gestational Diabetes.

Author information

1
Klinik und Poliklinik für Radiologie, Ludwig Maximilians University Hospital, Munich, Germany.
2
Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians University Hospital, Munich, Germany.
3
Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.
4
Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.

Abstract

Context:

Pancreatic steatosis may contribute to β-cell dysfunction in type 2 diabetes (T2D), but data are controversial. Women who had gestational diabetes mellitus (GDM) are at high risk for developing T2D.

Objective:

To examine the association of pancreatic fat content with early/first-phase insulin secretion (as markers of β-cell function).

Design:

Cross-sectional analysis of a subcohort of the monocentric, prospective cohort study titled Prediction, Prevention, and Subclassification of Type 2 Diabetes.

Setting:

Ludwig Maximilians University Hospital, Munich, Germany.

Participants:

Ninety-seven women, 3 to 16 months after pregnancy [41 normoglycemic women post-GDM, 19 women post-GDM with pathological glucose metabolism, and 37 normoglycemic women after a normoglycemic pregnancy (controls)].

Main Outcome Measures:

Correlation of MRI-measured pancreatic fat content with early insulin release in an oral glucose tolerance test (OGGT) [insulin increment within the first 30 minutes of the OGTT (IR30)] and first-phase insulin response (FPIR) in an intravenous glucose tolerance test (n = 65), both adjusted for insulin sensitivity index (ISI).

Results:

Pancreatic fat content did not correlate with IR30 and FPIR adjusted for ISI. It correlated positively with body mass index, waist circumference, liver fat, and intraabdominal fat volume.

Conclusion:

Pancreatic fat content does not correlate with β-cell function in a cohort of young women with different degrees of T2D risk.

PMID:
29947782
DOI:
10.1210/jc.2018-00187
[Indexed for MEDLINE]

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