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Bratisl Lek Listy. 2018;119(6):385-390. doi: 10.4149/BLL_2018_071.

The impact of TFPI on coronary atherosclerotic burden.

Abstract

OBJECTIVES:

We aimed to associate a coronary artery disease (CAD) presence and severity with endothelial dysfunction (ED), carotid intima media thickness (CIMT) and Tissue Factor Pathway Inhibitor (TFPI).

BACKGROUND:

ED has a central role in atherosclerosis. CIMT and TFPI activity are also related with atherosclerosis and CAD.

METHODS:

In our prospective observational study, 50 patients had CAD and 30 had normal coronary arteries. Endothelial function was evaluated by endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerine-mediated dilatation (NMD) measurements. CIMT and Serum TFPI levels were also measured.

RESULTS:

TFPI was a statistically significant determinant between the two groups with an increased level in CAD (+) group (84.9 ± 19.3 vs 70.2 ± 14.7, p = 0.001). There was a positive correlation between CIMT and Gensini (r = 0.34, p = 0.014). There was a strong negative correlation between Gensini and FMD-NMD, statistically significant (FMD: r = -0.715, p < 0.001; NMD: r = -0.718, p < 0.001).

CONCLUSION:

We observed that ED, increased CIMT and TFPI levels were associated with CAD. Additionally, increased CIMT measurements and decreased FMD and NMD values had a positive correlation with GSS (Tab. 4, Fig. 6, Ref. 50).

KEYWORDS:

coronary artery disease; endothelial dysfunction tissue factor pathway inhibitor.

PMID:
29947240
DOI:
10.4149/BLL_2018_071
[Indexed for MEDLINE]

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