Format

Send to

Choose Destination
Aging Clin Exp Res. 2019 Jan;31(1):151-155. doi: 10.1007/s40520-018-0989-7. Epub 2018 Jun 26.

Frailty modifications and prognostic impact in older patients admitted in acute care.

Author information

1
Unit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n. 1, Policlinico pad B, 98125, Messina, Italy. giorgio.basile@unime.it.
2
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. giorgio.basile@unime.it.
3
Unit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n. 1, Policlinico pad B, 98125, Messina, Italy.
4
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
5
Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
6
Unit for Metabolic Medicine, Cardiovascular Division, King's College London, London, UK.
7
Department of Economics, University of Messina, Messina, Italy.
8
Université de Toulouse III Paul Sabatier, Toulouse, France.

Abstract

BACKGROUND:

Frailty is a predictor of adverse outcomes in older subjects.

AIMS:

The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes.

METHODS:

Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge.

RESULTS:

A statistically significant difference was reported between the aFI (0.31, IQR 0.19-0.44) and the dFI (0.29, IQR 0.19-0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0-17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4-12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2-17.9, p = 0.03).

CONCLUSION:

Frailty is a strong predictor of negative endpoints in hospitalized older persons.

DISCUSSION:

Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.

KEYWORDS:

Elderly; Frailty; Hospitalization; Length of stay; Mortality

PMID:
29946755
DOI:
10.1007/s40520-018-0989-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center