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Development. 2018 Jun 26;145(12). pii: dev164368. doi: 10.1242/dev.164368.

What does time mean in development?

Author information

1
RIKEN Center for Biosystems Dynamics Research (RIKEN BDR), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan miki.ebisuya@riken.jp james.briscoe@crick.ac.uk.
2
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK miki.ebisuya@riken.jp james.briscoe@crick.ac.uk.

Abstract

Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic reactions to the glacial millions of years of evolutionary change. Falling somewhere in the middle of this range are the processes we usually study in development: cell division and differentiation, gene expression, cell-cell signalling, and morphogenesis. But what sets the tempo and manages the order of developmental events? Are the order and tempo different between species? How is the sequence of multiple events coordinated? Here, we discuss the importance of time for developing embryos, highlighting the necessity for global as well as cell-autonomous control. New reagents and tools in imaging and genomic engineering, combined with in vitro culture, are beginning to offer fresh perspectives and molecular insight into the origin and mechanisms of developmental time.

PMID:
29945985
PMCID:
PMC6031406
DOI:
10.1242/dev.164368
[Indexed for MEDLINE]
Free PMC Article

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