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Environ Health Prev Med. 2018 Jun 26;23(1):28. doi: 10.1186/s12199-018-0715-2.

The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol.

Author information

1
Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. kazun@med.niigata-u.ac.jp.
2
Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
3
Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoyahigashimachi, Nara, 630-8506, Japan.
4
Department of Health and Nutrition, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 951-3198, Japan.
5
Department of Physical Therapy, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 951-3198, Japan.
6
Department of Rehabilitation, Niigata University of Rehabilitation, 2-16 Kaminoyama, Murakami, Niigata, 958-0053, Japan.
7
Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
8
Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
9
Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oonohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
10
Murakami Public Health Center, 10-15 Sakanamachi, Murakami, Niigata, 958-0864, Japan.
11
Niigata Prefectural Office, 4-1 Shinkocho, Chuo-ku, Niigata, 950-0965, Japan.

Abstract

BACKGROUND:

Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeletal and other age-related diseases, and to clarify the association between vitamin D status and such diseases.

METHODS:

We targeted 34,802 residents aged 40-74 years living in areas of northern Niigata Prefecture, including Sekikawa Village, Awashimaura Village, and Murakami City (Murakami region). The baseline questionnaire survey, conducted between 2011 and 2013, queried respondents on their lifestyle and environmental factors (predictors), and self-reported outcomes. Plasma 25-hydroxyvitamin D (25[OH]D) concentration, an indicator of vitamin D status, was determined with the Liaison® 25OH Vitamin D Total Assay. The primary outcome of this study was osteoporotic fracture; other outcomes included age-related diseases including knee osteoarthritis, perception of chronic pain, dementia, and long-term care insurance use. Mean ages of men and women were 59.2 (SD = 9.3, N = 6907) and 59.0 (SD = 9.3, N = 7457) years, respectively. From the blood samples provided by 3710 men and 4787 women, mean 25(OH)D concentrations were 56.5 (SD = 18.4) nmol/L (22.6 ng/mL) and 45.4 (SD = 16.5) nmol/L (18.2 ng/mL), respectively.

DISCUSSION:

Follow-up surveys are planned every 5 years for 15 years, and incident cases of our targeted diseases will be followed at hospitals and clinics in and nearby the cohort area. We anticipate that we will be able to clarify the association between vitamin D status and multiple disease outcomes in a Japanese population.

KEYWORDS:

Cohort studies; Dementia; Musculoskeletal diseases; Osteoporotic fractures; Vitamin D

PMID:
29945572
PMCID:
PMC6020305
DOI:
10.1186/s12199-018-0715-2
[Indexed for MEDLINE]
Free PMC Article

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