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Mycoses. 2018 Nov;61(11):833-836. doi: 10.1111/myc.12820. Epub 2018 Jul 13.

EQUAL Aspergillosis Score 2018: An ECMM score derived from current guidelines to measure QUALity of the clinical management of invasive pulmonary aspergillosis.

Author information

1
Department I for Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
2
CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
3
Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.

Abstract

Invasive pulmonary aspergillosis is a serious threat to immunocompromised and critical care patients. Recent detailed guidelines and treatment algorithms lead microbiologists and clinicians in diagnosis and treatment of invasive aspergillosis. Currently, there is no tool available that allows to measure guideline adherence. To develop such a tool, we reviewed current guidelines provided by five scientific societies (European Society for Clinical Microbiology and Infectious Diseases, European Confederation of Medical Mycology, European Respiratory Society, Infectious Diseases Society of America (IDSA), and Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology) and selected the strongest recommendations for management as key components for our scoring tool. We integrated diagnostic measures (chest computed tomography, bronchoalveolar lavage with galactomannan, fungal culture, fungal polymerase chain reaction analysis, species identification, susceptibility testing, histology with silver stain, Periodic acid-Schiff staining, and molecular diagnostics), treatment (antifungal choice and therapeutic drug monitoring), and follow-up computed tomography. The EQUAL Aspergillosis Score 2018 aggregates and weighs the components and provides a tool to support antifungal stewardship and to quantify guideline adherence.

KEYWORDS:

Aspergillus; diagnosis and treatment; fungal infections; guideline adherence

PMID:
29944740
DOI:
10.1111/myc.12820
[Indexed for MEDLINE]

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