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Clin Schizophr Relat Psychoses. 2018 Jun 26. doi: 10.3371/CSRP.SCWO.061518. [Epub ahead of print]

An Exploratory Study of Exercise-related Effects on Memory and Hippocampal Connectivity in Schizophrenia.

Author information

1
Mental Health Service, Washington DC Veterans Affairs Medical Center.
2
Cardiology Division, Washington DC Veterans Affairs Medical Center.
3
Current affiliation: Dr. Theresa Teslovich's current address is the National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, Mr. Jae Cho's current address is Department of Psychology, George Mason University, Fairfax, VA.
4
Departments of Psychiatry, Georgetown University, Washington, DC.
5
Psychology, Georgetown University, Washington, DC.
6
Center for Neuroscience, National Children's Medical Center, Washington DC.
7
Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, New York.

Abstract

Memory impairment in schizophrenia has been linked to abnormal functioning of fronto-temporal networks. In this pilot study, we investigated whether 12-weeks of exercise improved hippocampal-dependent memory functions and resting-state functional connectivity in middle-aged adults with schizophrenia. The exercise regimen was feasible, well-attended, and safe. There was a pre- to post-intervention increase in spatial memory accuracy that was correlated to an increase in hippocampal-prefrontal cortex connectivity. No increase was found in pattern separation performance or hippocampal volume. A controlled trial is needed to replicate these findings and elucidate the functional brain networks underlying exercise-induced cognitive improvement in schizophrenia.

KEYWORDS:

Aerobic exercise; Anterior hippocampal connectivity; Spatial memory

PMID:
29944414
DOI:
10.3371/CSRP.SCWO.061518

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