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Acad Radiol. 2019 Feb;26(2):154-160. doi: 10.1016/j.acra.2018.05.010. Epub 2018 Jun 23.

Association Between BRAFV600E Mutation and the American College of Radiology Thyroid Imaging, Reporting and Data System in Solitary Papillary Thyroid Carcinoma.

Author information

1
Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou 325000, China. Electronic address: shangguanronger@163.com.
2
Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou 325000, China. Electronic address: huyuanping1@hotmail.com.
3
Department of Echocardiography, The Affiliated Changzhou No.2 People's Hospital With Nanjing Medical University, Changzhou 213003, China.
4
Department of Ultrasonography, The First Hospital Affiliated to Zhejiang University, Hangzhou 310003, China.
5
Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou 325000, China.
6
Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Abstract

RATIONALE AND OBJECTIVES:

The purpose of this study was to evaluate the associations between BRAFV600E mutation, the American College of Radiology (ACR) thyroid imaging, reporting and data system (TI-RADS) on ultrasound and clinicopathological characteristics in patients with a solitary papillary thyroid carcinoma (PTC).

MATERIALS AND METHODS:

This retrospective study included 397 patients with a solitary PTC, proved pathologically. BRAFV600E mutation status was detected in postoperative samples by real-time fluorescent polymerase chain reaction. Associations of BRAFV600E mutation with the ACR TI-RADS and clinicopathological characteristics were analyzed.

RESULTS:

In this study, the incidence of BRAFV600E mutation was 81.4% (323/397) in patients with a solitary PTC. Univariate analyses showed that BRAFV600E mutation was significantly associated with margin, higher ACR TI-RADS point scores, and Hashimoto's thyroiditis. In multivariate analyses, lobulated or irregular margin was independently associated with BRAFV600E mutation in total solitary PTC. Furthermore, both in total solitary PTC and papillary thyroid microcarcinoma, BRAFV600E mutation was associated with ACR TI-RADS point scores, which was positively correlated with the risk of BRAFV600E mutation. There was no significant relationship between BRAFV600E mutation and ACR TI-RADS point scores in PTC >10 mm. In addition, Hashimoto's thyroiditis had a significant negative association with BRAFV600E mutation.

CONCLUSION:

A lobulated or irregular margin of the thyroid nodule is independently associated with BRAFV600E mutation in patients with PTC. In addition, higher ACR TI-RADS point scores is an independent risk factor for BRAFV600E mutation, and ACR TI-RADS point scores is positively associated with the risk of BRAFV600E mutation in solitary PTC, especially in papillary thyroid microcarcinoma. Our findings may be helpful for preoperative identification and medical management of PTC patients with BRAFV600E mutation.

KEYWORDS:

ACR TI-RADS; BRAF(V600E) mutation; Hashimoto's thyroiditis; PTC; Ultrasound

PMID:
29941398
DOI:
10.1016/j.acra.2018.05.010

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