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Trends Cell Biol. 2018 Aug;28(8):589-591. doi: 10.1016/j.tcb.2018.06.004. Epub 2018 Jun 22.

Yeast and Human Nuclear Pore Complexes: Not So Similar After All.

Author information

1
The Mina and Everard Goodman Faculty of Life Sciences, and Institute of Nanotechnology, Bar-Ilan University, Ramat Gan 5290002, Israel. Electronic address: Yaron.Shav-Tal@biu.ac.il.
2
Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Umshing, Shillong 793022, Meghalaya, India. Electronic address: timir.tripathi@gmail.com.

Abstract

Nucleoporin subunits that generate the nuclear pore complex (NPC) are highly conserved in evolution. High-resolution structures of the NPC are available, but the actual NPC composition in yeast has only been quantified recently. Two studies reveal major differences between species, suggesting high flexibility in NPC structures during evolution.

KEYWORDS:

NPC structure; evolution; nuclear pore complex; nucleoporins

PMID:
29941187
DOI:
10.1016/j.tcb.2018.06.004
[Indexed for MEDLINE]

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