Format

Send to

Choose Destination
BMC Complement Altern Med. 2018 Jun 25;18(1):195. doi: 10.1186/s12906-018-2199-4.

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.

Author information

1
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
2
China-ASEAN College of Marine Sciences, Xiamen University Malaysia, Jalan Sunsuria, Bandar Sunsuria, 43900, Sepang, Selangor, Malaysia.
3
Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
4
Biotechnology Research Centre, Malaysian Agricultural Research and Development Institute (MARDI), 43400, Serdang, Selangor, Malaysia.
5
Department of Genetics and Plant Breeding, College of Agriculture and Applied Biology, Cantho University, 3/2 Street, CanTho City, Vietnam.
6
Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Sungai Long Campus, Jalan Sungai Long, Bandar Sungai Long, Cheras, 43000, Kajang, Selangor, Malaysia.
7
School of Biomedical Sciences, the University of Nottingham Malaysia Campus, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.
8
Biotechnology Research Centre, Malaysian Agricultural Research and Development Institute (MARDI), 43400, Serdang, Selangor, Malaysia. amai@mardi.gov.my.
9
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. noorjahan@upm.edu.my.
10
Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. noorjahan@upm.edu.my.

Abstract

BACKGROUND:

Coconut water has been commonly consumed as a beverage for its multiple health benefits while vinegar has been used as common seasoning and a traditional Chinese medicine. The present study investigates the potential of coconut water vinegar in promoting recovery on acetaminophen induced liver damage.

METHODS:

Mice were injected with 250 mg/kg body weight acetaminophen for 7 days and were treated with distilled water (untreated), Silybin (positive control) and coconut water vinegar (0.08 mL/kg and 2 mL/kg body weight). Level of oxidation stress and inflammation among treated and untreated mice were compared.

RESULTS:

Untreated mice oral administrated with acetaminophen were observed with elevation of serum liver profiles, liver histological changes, high level of cytochrome P450 2E1, reduced level of liver antioxidant and increased level of inflammatory related markers indicating liver damage. On the other hand, acetaminophen challenged mice treated with 14 days of coconut water vinegar were recorded with reduction of serum liver profiles, improved liver histology, restored liver antioxidant, reduction of liver inflammation and decreased level of liver cytochrome P450 2E1 in dosage dependent level.

CONCLUSION:

Coconut water vinegar has helped to attenuate acetaminophen-induced liver damage by restoring antioxidant activity and suppression of inflammation.

KEYWORDS:

Acetification; Cocos nucifera; Inflammation; Paracetamol; Phenolic

PMID:
29940935
PMCID:
PMC6019733
DOI:
10.1186/s12906-018-2199-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center