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Neoplasma. 2018;65(4):572-578. doi: 10.4149/neo_2018_170814N530.

miR-129-5p suppresses breast cancer proliferation by targeting CBX4.

Meng R1,2,3, Fang J1,2,3,4, Yu Y1,2,3, Hou LK1,2,3, Chi JR1,2,3, Chen AX1,2,3, Zhao Y1,2,3, Cao XC1,2,3.

Author information

1
The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China
2
Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
3
Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China
4
Department of Head-neck and Breast Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China

Abstract

Deregulation of microRNA (miRNA) is closely related to cancer development and progression. Our previous study identified that miR-129-5p suppresses proliferation and metastasis in breast cancer cells. Herein, we determined that CBX4 is a miR-129-5p target gene. CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression. These combined results suggest that CBX4 is an oncogene in breast cancer cells, and that it may provide a novel therapeutic strategy for breast cancer treatment.

KEYWORDS:

CBX4; miR-129-5p; proliferation breast cancer.

PMID:
29940764
DOI:
10.4149/neo_2018_170814N530
[Indexed for MEDLINE]

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