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Int J Sports Med. 2018 Oct;39(10):743-748. doi: 10.1055/a-0633-8892. Epub 2018 Jun 25.

Eccentric Overload Muscle Damage is Attenuated By a Novel Angiotensin- (1-7) Treatment.

Author information

1
Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil.
2
National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
3
Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil.
4
Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Abstract

The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46±0.64 vs. placebo 3.80±0.77 cm) and 24 h after exercise (3.07±0.71 vs. 3.73±0.58 cm placebo) and higher MS at 24 h (24±12 N) and 48 h (30±15 N) vs. placebo (-8±9 N and -10±9 N). The CK for Ang-(1-7) (0.5±0.1 and 0.9±0.2 U/L) were lower at 48 and 72 h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38±2.5 pg/ml) vs. placebo (45±2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.

PMID:
29940668
DOI:
10.1055/a-0633-8892
[Indexed for MEDLINE]

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