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Nature. 1985 Sep 12-18;317(6033):145-53.

Structure of a human common cold virus and functional relationship to other picornaviruses.

Abstract

We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.

PMID:
2993920
DOI:
10.1038/317145a0
[Indexed for MEDLINE]

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