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Br J Haematol. 2019 Apr;185(1):169-174. doi: 10.1111/bjh.15425. Epub 2018 Jun 25.

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia.

Author information

1
Department of Paediatrics and Genetics, Ghent University, Ghent, Belgium.
2
Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
3
Molecular and Cellular Oncology Laboratory, Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
4
VIB Inflammation Research Centre, Ghent University, Ghent, Belgium.
5
Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
6
Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
7
Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
8
Department of Pathology and the Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN, USA.
9
The Cancer Centre for Children, The Children's Hospital, Westmead, Australia.
10
University of Alabama at Birmingham, Birmingham, AL, USA.
11
Women and Child Health Department, Haematology-Oncology Laboratory Istituto di Ricerca Pediatrica (IRP), University of Padova, Padova, Italy.
12
Department of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris, France.
13
Children's Cancer Institute, Lowy Cancer Research Centre UNSW, Sydney, New South Wales, Australia.
14
Laboratory of Onco-Haematology, Institut Necker Enfants-Malades, INSERM U1151, Paris, France.
15
The Máxima Centre for Paediatric Oncology/Haematology, Utrecht, the Netherlands.
16
Department of Pediatrics, UCSF Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.

KEYWORDS:

BRD4 inhibition; T cell acute lymphoblastic leukaemia; t(8;14)(q24;q11) translocation

PMID:
29938777
DOI:
10.1111/bjh.15425

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