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Curr Diab Rep. 2018 Jun 25;18(8):59. doi: 10.1007/s11892-018-1021-5.

Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment.

Author information

1
College of Medical, Veterinary and Life Sciences, University of Glasgow, Room 113, 1 Lilybank Gardens, Glasgow, G12 8RZ, UK.
2
Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
3
Wellcome Centre Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, Oxfordshire, OX3 7BN, UK. nvanzuy@well.ox.ac.uk.
4
Oxford Centre for Diabetes Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, Oxfordshire, OX3 7LE, UK. nvanzuy@well.ox.ac.uk.

Abstract

PURPOSE OF REVIEW:

The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal contribution of common risk factors to T2D and CVD and how genetics can be used to improve drug development and clinical outcomes.

RECENT FINDINGS:

Large-scale genome-wide association studies (GWAS) of T2D and CVD support a shared genetic background but minimal individual locus overlap. Mendelian randomisation (MR) analyses show that T2D is causal for CVD, but GWAS of CVD, T2D and their common risk factors provided limited evidence for individual locus overlap. Distinct but functionally related pathways were enriched for CVD and T2D genetic associations reflecting the lack of locus overlap and providing some explanation for the variable associations of common risk factors with CVD and T2D from MR analyses.

KEYWORDS:

Coronary artery disease; Genetics; Mendelian randomisation; Ischemic stroke; Peripheral artery disease; Risk factors; Type 2 diabetes

PMID:
29938349
PMCID:
PMC6015804
DOI:
10.1007/s11892-018-1021-5
[Indexed for MEDLINE]
Free PMC Article

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