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Trends Biotechnol. 2018 Oct;36(10):1011-1024. doi: 10.1016/j.tibtech.2018.05.009. Epub 2018 Jun 21.

The Vascularised Chamber as an In Vivo Bioreactor.

Author information

1
O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Department of Plastic and Reconstructive Surgery, St Vincent's Hospital Melbourne, Victoria, Australia. Electronic address: kyap@svi.edu.au.
2
Harry Perkins Institute of Medical Research and Centre for Medical Research, University of Western Australia, Western Australia, Australia.
3
O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Department of Plastic and Reconstructive Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Australian Catholic University, Victoria, Australia.
4
O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Australian Catholic University, Victoria, Australia.

Abstract

Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space surgically created and embedded within the body by fitting a noncollapsible chamber around major blood vessels. This creates a highly angiogenic environment which facilitates the engraftment and survival of transplanted cells and tissue constructs. This article outlines the chamber concept and explores its application in the context of recent advances in biomedical engineering, and how this can play a role in the future of cell therapies and regenerative medicine.

KEYWORDS:

angiogenesis; bioengineering; cell therapy; stem cells; tissue engineering; transplantation; vascularised chamber

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