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Trends Cancer. 2018 Jul;4(7):468-471. doi: 10.1016/j.trecan.2018.05.004. Epub 2018 Jun 7.

The Value of Outbred Rodent Models in Cancer Research.

Author information

1
Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
2
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, SC, USA.
3
Peromyscus Genetic Stock Center, University of South Carolina, SC, USA.
4
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, University of South Carolina, SC, USA. Electronic address: kiarish@cop.sc.edu.

Abstract

Mouse models of breast cancer are valuable research tools, but their usefulness is restricted by a series of features inherent to their physiology, such as low endogenous estrogens and genetics (inbred status). Depending on the specific questions asked, outbred rodents like Peromyscus may provide answers that laboratory mice cannot.

KEYWORDS:

hormone-sensitive breast cancer; host diversity; outbred model; xenograft

PMID:
29937045
DOI:
10.1016/j.trecan.2018.05.004
[Indexed for MEDLINE]

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