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J Affect Disord. 2018 Oct 1;238:526-533. doi: 10.1016/j.jad.2018.05.080. Epub 2018 Jun 21.

Involvement of prolactin in newborn infant irritability following maternal perinatal anxiety symptoms.

Author information

1
Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
2
Shaanxi Institute of Pediatric Diseases, The Affiliated Children Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710003, China.
3
Shaanxi Province Biomedicine Key Laboratory, College of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address: zlzhu@xjtu.edu.cn.
4
Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China. Electronic address: huili@mail.xjtu.edu.cn.

Abstract

BACKGROUND:

Newborn irritability could be an unique and special status and/or adverse neurobehavioral outcomes which was independent of serious disease. To determine whether maternal perinatal anxiety symptoms was associated with newborn irritability, and whether the alteration of serum prolactin in newborns were involved in newborn irritability.

METHODS:

205 pregnant women were recruited: normal group (n = 100), and anxiety group (n = 105), which was randomly divided to Newborn Behavioral Observations (NBO)+anxiety group(n = 65) and control+anxiety group(n = 40). Newborn Irritability was assessed by Neonatal Behavioral Assessment Scale(NBAS). Serum prolactin, cortisol and 5-HT in mothers and infants were measured.

RESULTS:

1. The scores of irritability items in the newborns of anxiety group were higher than that of the normal group (p < 0.05). 2. Lower serum PRL, 5-HT and higher serum cortisol were found in the newborns of anxiety group compared with that of the control group both postpartum 2d and 15 (p < 0.05). 3. The level of serum PRL in newborn infants were significantly and negatively correlated to the scores of irritability items (p < 0.05). 4. After 7 rounds of NBO interventions, the anxiety scores of mothers and the scores of irritability items of newborns in the NBO intervention group were all lower than those of the control group (p < 0.05) .

LIMITATIONS:

In future experiments, we should explore the effect of PRL in the breast milk on newborn infant serum PRL.

CONCLUSIONS:

Prolactin could be a potential mediator in newborn irritability following maternal perinatal anxiety symptoms.

KEYWORDS:

Maternal anxiety; Newborn irritability; Perinatal; Prolactin

PMID:
29936391
DOI:
10.1016/j.jad.2018.05.080
[Indexed for MEDLINE]

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