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Fertil Steril. 2018 Jul 1;110(1):122-127. doi: 10.1016/j.fertnstert.2018.03.015. Epub 2018 Jun 20.

Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study.

Author information

1
Department of Obstetrics and Gynecology, Uludag University School of Medicine, Bursa, Turkish Republic.
2
Department of Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkish Republic.
3
Department of Obstetrics and Gynecology, Koc University Hospital, Istanbul, Turkish Republic.

Abstract

OBJECTIVE:

To evaluate whether endometrioma is associated with a progressive decline in ovarian reserve, and to compare the rate of decline with natural decline in ovarian reserve.

DESIGN:

Prospective, observational study.

SETTING:

Tertiary university hospital, endometriosis clinic.

PATIENT(S):

Forty women with endometrioma and 40 age-matched healthy controls.

INTERVENTION(S):

Women with endometriomas who did not need hormonal/surgical treatment at the time of recruitment and were expectantly managed. Controls were age-matched, healthy women. All participants underwent serum antimüllerian hormone (AMH) testing twice, 6 months apart. Sexually active patients with endometrioma also underwent antral follicle count.

MAIN OUTCOME MEASURE(S):

Change in serum AMH levels.

RESULT(S):

Median (25th-75th percentile) serum AMH level at recruitment was 2.83 (0.70-4.96) ng/mL in the endometrioma group and 4.42 (2.26-5.57) ng/mL in the control group. The median percent decline in serum AMH level was 26.4% (11.36%-55.41%) in the endometrioma group and 7.4% (-11.98%, 29.33%) in the control groups. Twenty-two women with endometrioma who had antral follicle count (AFC) had median AFC of 10 (8-12) at recruitment and 8 (6.3-10) at 6 months.

CONCLUSION(S):

Women with endometrioma experience a progressive decline in serum AMH levels, which is faster than that in healthy women.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT02438735.

KEYWORDS:

Antimüllerian hormone; endometrioma; endometriosis; ovarian reserve

[Indexed for MEDLINE]

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