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Reprod Biol Endocrinol. 2018 Jun 23;16(1):61. doi: 10.1186/s12958-018-0378-2.

Sugar-sweetened beverage intake and serum testosterone levels in adult males 20-39 years old in the United States.

Author information

1
The First Division in the Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106th of Zhongshan Er Road, Guangzhou, 510080, China. liangchen2@medsub.cn.
2
GuangDong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. yumeixie33@medsub.cn.
3
The First Division in the Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106th of Zhongshan Er Road, Guangzhou, 510080, China.

Abstract

BACKGROUND:

This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20-39 years old.

METHODS:

All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity.

RESULTS:

Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m2 had a higher risk of having a low testosterone level than those with BMI < 25 kg/m2 (aOR = 3.68, p = 0.044).

CONCLUSION:

SSB consumption is significantly associated with low serum testosterone in men 20-39 years old in the United States.

KEYWORDS:

Hypogonadism; National Health and nutrition examination survey (NHANES); Sugar-sweetened beverages (SSBs); Testosterone

PMID:
29935533
PMCID:
PMC6015465
DOI:
10.1186/s12958-018-0378-2
[Indexed for MEDLINE]
Free PMC Article

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