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Curr Opin Immunol. 2018 Oct;54:7-12. doi: 10.1016/j.coi.2018.05.005. Epub 2018 Jun 21.

Cytokine modulation of atopic itch.

Author information

1
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110 USA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA.
2
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110 USA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110 USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA. Electronic address: briankim@wustl.edu.

Abstract

Atopic dermatitis (AD) is an inflammatory skin disease characterized by two primary features: relapsing skin lesions and chronic itch. Major advances in our understanding of type 2 immunity have led to new insights into the critical factors that promote the development and persistence of AD-associated skin inflammation. Although inflammation is strongly associated with the development of atopic itch, the precise mechanisms by which itch arises in AD are poorly understood. In this review, we highlight recent studies that have started to unveil how various proinflammatory factors released within the skin can elicit sensations of itch and discuss the therapeutic potential of targeting these neuroimmunologic processes.

PMID:
29935376
DOI:
10.1016/j.coi.2018.05.005
[Indexed for MEDLINE]

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