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Prog Mol Biol Transl Sci. 2018;157:175-232. doi: 10.1016/bs.pmbts.2018.01.006. Epub 2018 Apr 11.

DNA Methylation and Psychiatric Disorders.

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University of Illinois, Chicago, IL, United States; School of Life Science, Central South University, Changsha, China. Electronic address:
School of Life Science, Central South University, Changsha, China.
Hunan Brain Hospital, Changsha, China.


DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review the mechanisms of DNA methylation, including the genetic and environmental factors affecting methylation changes. We report and discuss major findings regarding DNA methylation in psychiatric patients, both within the context of global methylation studies and gene-specific methylation studies. Finally, we discuss issues surrounding data quality improvement, the limitations of current methylation analysis methods, and the possibility of using DNA methylation-based treatment for psychiatric disorders in the future.


DNA methylation; EWAS; epigenomics; gene expression; pathway; psychiatric disorders

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