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Kidney Int. 2018 Jul;94(1):16-18. doi: 10.1016/j.kint.2018.03.009.

IgA nephropathy: new insights into the role of complement.

Author information

1
Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany. Electronic address: Juergen.floege@rwth-aachen.de.
2
Department of Nephrology, University Medical Center Leiden and University Medical Center Groningen, Groningen, The Netherlands.

Abstract

Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H-related proteins in IgA nephropathy, which might contribute to enhanced complement activation.

PMID:
29933843
DOI:
10.1016/j.kint.2018.03.009
[Indexed for MEDLINE]

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