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Kidney Int. 2018 Jul;94(1):14-16. doi: 10.1016/j.kint.2018.03.010.

The net effect of ANCA on neutrophil extracellular trap formation.

Author information

1
Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: p.heeringa@umcg.nl.
2
Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Abstract

The formation of neutrophil extracellular traps induced by antineutrophil cytoplasmic autoantibodies has been implicated in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis. Kraaij et al. now provide evidence that excessive neutrophil extracellular trap formation in vitro induced by sera from patients with antineutrophil cytoplasmic autoantibody-associated vasculitis is associated with active disease but is not dependent on the presence of antineutrophil cytoplasmic autoantibodies.

PMID:
29933842
DOI:
10.1016/j.kint.2018.03.010

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