Trends Neurosci. 2018 Jul;41(7):407-409. doi: 10.1016/j.tins.2018.04.008.

Revealing the Genetic Instructions for Nervous System Wiring.

Author information

1: Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Electronic address: kevin.mitchell@tcd.ie.

Abstract

Why did the axon cross the midline? A 1993 paper by Corey Goodman and colleagues described a genetic screen in fruit flies that pioneered the discovery of conserved families of axon guidance cues and receptors, highlighting fundamental processes underlying wiring specificity in the developing nervous system.