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Stress. 2019 Jan;22(1):36-43. doi: 10.1080/10253890.2018.1484445. Epub 2018 Jun 22.

Infant cortisol stress-response is associated with thymic function and vaccine response.

Author information

1
a Nutrition Department , University of California , Davis , CA , USA.
2
b US Department of Agriculture , Western Human Nutrition Research Center , Davis , CA , USA.
3
c Enteric and Respiratory Infections Unit, Infectious Diseases Division, icddr,b , Dhaka , Bangladesh.
4
d Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine , University of Tsukuba , Tsukuba , Japan.

Abstract

Stress can impair T cell-mediated immunity. To determine if infants with high stress responses had deficits in T-cell mediated immunity, we examined the association of pain-induced cortisol responsiveness with thymic function and vaccine responses in infants. This study was performed among 306 (male = 153 and female = 153) participants of a randomized, controlled trial examining the effect of neonatal vitamin A supplementation on immune function in Bangladesh (NCT01583972). Salivary cortisol was measured before and 20 min after a needle stick (vaccination) at 6 weeks of age. The thymic index (TI) was determined by ultrasonography at 1, 6, 10 and 15 weeks. T-cell receptor excision circle and blood T-cell concentrations were measured at 6 and 15 weeks. Responses to Bacillus Calmette-Guérin (BCG), tetanus toxoid, hepatitis B virus and oral poliovirus vaccination were assayed at 6 and 15 weeks. Cortisol responsiveness was negatively associated with TI at all ages (p < .01) in boys only, was negatively associated with naïve helper T-cell concentrations in both sexes at both 6 (p = .0035) and 15 weeks (p = .0083), and was negatively associated with the delayed-type hypersensitivity (DTH) skin test response to BCG vaccination at 15 weeks (p = .034) in both sexes. Infants with a higher cortisol response to pain have differences in the T-cell compartment and a lower DTH response to vaccination. Sex differences in the immune system were seen as early as 6 weeks of age in these healthy infants.

KEYWORDS:

Stress; T-cell; cortisol; thymus; vaccine; vitamin A

PMID:
29932814
PMCID:
PMC6351220
[Available on 2020-01-01]
DOI:
10.1080/10253890.2018.1484445
[Indexed for MEDLINE]

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