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Front Psychiatry. 2018 Jun 7;9:252. doi: 10.3389/fpsyt.2018.00252. eCollection 2018.

Longitudinal Changes in Neural Connectivity in Patients With Internet Gaming Disorder: A Resting-State EEG Coherence Study.

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Department of Psychiatry SMG-SMU Boramae Medical Center, Seoul, South Korea.
Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine Catholic University of Korea, Seoul, South Korea.
Department of Psychiatry Seoul Medical Center, Seoul, South Korea.
Department of Psychiatry and Behavioral Science Seoul National University College of Medicine, Seoul, South Korea.


Aims: The present study investigated neural connectivity associated with treatment responses in patients with Internet gaming disorder (IGD) using resting-state electroencephalography (EEG) coherence analyses. Methods: We included 30 patients with IGD and 32 healthy control subjects (HCs). Of the IGD patients, 18 completed an outpatient treatment that included pharmacotherapy with selective serotonin reuptake inhibitors for 6 months. Resting-state EEG coherence and self-report questionnaires were used to evaluate clinical and psychological features pre- and post-treatment, and data were analyzed using generalized estimating equations. Results: Compared with HCs, patients with IGD showed increased beta and gamma intrahemispheric coherence and increased delta intrahemispheric coherence of the right hemisphere at baseline. After 6 months of outpatient management, patients with IGD exhibited improvements in IGD symptoms compared with baseline, but they continued to show increased beta and gamma intrahemispheric coherence compared with that of HCs. No significant EEG coherence changes between the pre- and post-treatment assessments were detected in any band in the IGD group. Conclusion: These findings suggest that significantly greater intrahemispheric fast-frequency coherence may be an important neurophysiological trait marker of patients with IGD.


EEG; coherence; fast frequency band; internet gaming disorder; treatment response

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