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Sci Rep. 2018 Jun 21;8(1):9462. doi: 10.1038/s41598-018-27833-z.

Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient.

Author information

1
Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU Méditerranée-infection, Marseille, France.
2
Centre de Référence des Infections Ostéo-Articulaires (CRIOA) Sud-Méditerranée, Service des Maladies Infectieuses Chroniques, Pôle Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
3
Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU Méditerranée-infection, Marseille, France. pierre-edouard.fournier@univ-amu.fr.
4
Centre de Référence des Infections Ostéo-Articulaires (CRIOA) Sud-Méditerranée, Service des Maladies Infectieuses Chroniques, Pôle Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France. pierre-edouard.fournier@univ-amu.fr.

Abstract

We sequenced the genome of Raoultella ornithinolytica strain Marseille-P1025 that caused a rare case of prosthetic joint infection in a 67-year-old immunocompetent male. The 6.7-Mb genome exhibited a genomic island (RoGI) that was unique among R. ornithinolytica strains. RoGI was likely acquired by lateral gene transfer from a member of the Pectobacterium genus and coded for a type IVa secretion system found in other pathogenic bacteria and that may have conferred strain Marseille-P1025 an increased virulence. Strain Marseille-P1025 was also able to infect, multiply within, and kill Acanthamoaeba castellanii amoebae.

PMID:
29930334
PMCID:
PMC6013458
DOI:
10.1038/s41598-018-27833-z
[Indexed for MEDLINE]
Free PMC Article

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