Format

Send to

Choose Destination
Eur J Prev Cardiol. 2018 Aug;25(12):1293-1302. doi: 10.1177/2047487318783892. Epub 2018 Jun 22.

Shift work and risk of cardiovascular disease morbidity and mortality: A dose-response meta-analysis of cohort studies.

Author information

1
1 Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China.
2
2 Wuhan Prevention and Treatment Center for Occupational Diseases, Wuhan, China.
3
3 Department of Clinical Medicine, Xi'an Medical University, China.
4
4 Department of Emergency, Wuhan Centers for Diseases Prevention and Control, China.
5
5 Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China.

Abstract

Background Previous studies have suggested that shift work is associated with a higher risk of cardiovascular disease. However, the quantitative dose-response relationship between duration of shift work and cardiovascular disease risk is still unknown. We aimed to evaluate the dose-response association between duration of shift work and risk of cardiovascular disease morbidity and mortality. Design A systematic review and meta-analysis. Methods PubMed and Embase were searched from inception to 1 December 2017. Prospective cohort studies that reported the associations between duration of shift work and cardiovascular disease risk with at least three categories were included. Data were pooled by using fixed or random effect models. The continuous dose-response associations were assessed by using fixed effect restricted cubic splines with four knots. Results Five prospective cohort studies with 10 reports were included. No evidence of a curvilinear association was observed between duration of shift work and risk of cardiovascular disease, similar findings were observed in cardiovascular disease morbidity and mortality. The summary relative risk (RR) of an increase of 5 years of shift work was 1.05 (1.04-1.07) with moderate heterogeneity ( P = 0.142, I2 = 33.2%) for cardiovascular disease, 1.06 (1.04-1.08) with low heterogeneity ( P = 0.279, I2 = 21.7%) for cardiovascular disease morbidity, and 1.04 (1.02-1.06) with moderate heterogeneity ( P = 0.135, I2 = 38.5%) for cardiovascular disease mortality, respectively. Conclusions Shift work could probably increase the risk of cardiovascular disease and cardiovascular disease mortality in a dose-response way. These findings could have implications for guideline recommendations regarding the risk related to shift schedules.

KEYWORDS:

Shift work; cardiovascular disease; morbidity; mortality

Comment in

PMID:
29929393
DOI:
10.1177/2047487318783892
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center